Analysis of Potential Drug-drug Interactions in Liver Cirrhosis Patients

Background: Patients with liver cirrhosis are at a high risk of drug interactions due to the use multi-drug combination regimens. Objectives: This study analyzed potential drug-drug in patients Gatot Soebroto Army Hospital, Jakarta 2016. Material and Methods: employed an observational-cross sectional design retrospective data collection patients' medical records. The were identified using Drug Interaction Facts 2012 including mechanism type, severity onset interactions. Results: As many as 88% experienced total 35 cases. highest proportions cases found pharmacokinetic by approximately 25 (71.43%), minor comprising 29 (82.86%) rapid 19 (54.29%). furosemide-propranolol 16 (45.72%). Conclusions: incidence requires vigilance close monitoring all health professionals achieving optimal therapeutic outcomes for patients.